Immunotherapy Drug Keytruda Halts 'Untreatable' Prostate Cancer In Some Men

Immunotherapy Drug Keytruda Halts 'Untreatable' Prostate Cancer In Some Men

"Our study has found that immunotherapy can benefit a subset of men with advanced, otherwise untreatable prostate cancer, and these are most likely to include patients who have specific DNA fix mutations within their tumours", said Johann de Bono, Director of the Drug Development Unit at the Institute of Cancer Research.

Researchers from The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust in London gave 258 men with the otherwise untreatable cancer the immunotherapy agent Keytruda (pembrolizumab).

"Our study has found that immunotherapy can benefit a subset of men with advanced, otherwise untreatable prostate cancer, and these are most likely to include patients who have specific DNA fix mutations within their tumors", he said.

In addition, he said, "This research shows that by providing equal access to treatment, we can reduce racial disparities in outcomes for men with advanced prostate cancer". These are medications which boost the immune system, and here trials have shown combination treatments to have have saved the lives of some men who were diagnosed with terminal prostate cancer.

With this study, George and colleagues hypothesized that black men with advanced prostate cancer would respond better to abiraterone than white men.

Previous clinical trials using the immunotherapy approach were unsuccessful proved to be unsuccessful in treating the prostate cancer patients efficiently. There are 47,000 new prostate cancer diagnoses annually in the United Kingdom alone, resulting in 11,000 deaths a year.

Germany Drop Sane, Name Ozil, Rudiger, Neuer, Kroos In World Cup Squad
He had not arrived in worldwide matches yet. "If it was a 100 metre race, it would have been a photo finish". The defending champions, Germany , have named their 23-man squad for the World Cup in Russian Federation .

"Our study provides prospective evidence that there might be inherited genes that could affect treatment response and track with African ancestry in prostate cancer patients", George said. Pembrolizumab is a humanized antibody used in cancer immunotherapy.

According to the researchers, a subset of men who had run out of all existing options for treatment "survived much longer than expected when taking immunotherapy". It can work only for a few patients.

Only around 20% of cancer patients respond to immunotherapy and researchers do not fully understand why.

The researchers also said that some of the patients who had substantial responses to the treatment have tumors that may have mutations in the genes that control DNA fix, an important cellular process that maintains the genome. Prostate cancer is the development of cancer in the prostate, a gland in the male reproductive system. It seems to work incredibly well for a handful of patients, have a temporary effect in others, and do nothing for the rest.

Research will now focus on identifying markers to help pick out the prostate cancer patients whose tumours are most likely to shrink after immunotherapy treatment.

Related Articles

  • Discovery buys PGA Tour global  rights for $2 billion

    Discovery buys PGA Tour global rights for $2 billion

    The 12-year partnership involves the development of a new PGA Tour-branded video streaming service, the company said. While known for unscripted programming like "Shark Week", Discovery is focused on becoming a global TV sports giant.

    Facebook Gave User Data To 60 Companies

    Facebook began shutting down the use of the APIs in April as part of its response to the Cambridge Analytica incident. It also said that the features couldn't be used with permission and that its engineering teams approved all of them.
    Trump lawyers' letter challenges subpoena

    Trump lawyers' letter challenges subpoena

    Giuliani told Fox News on May 12 that Mueller notified Trump's legal team two weeks prior that he will not indict the president. In a Saturday tweet , Trump asked whether the special counsel or Justice Department had leaked the letter to the media.
  • Trump Rips Into Justice Department/FBI for Not Warning Him About Manafort

    Trump Rips Into Justice Department/FBI for Not Warning Him About Manafort

    They lobbied and conducted public relations work in Europe and the U.S.in 2012 and 2013, US prosecutors said in court filings. Jason Maloni says in a statement that Manafort is innocent and "nothing about this latest allegation changes our defense".
    PM won't rule out financial support for steel, aluminum workers

    PM won't rule out financial support for steel, aluminum workers

    Business leaders in the USA and Canada say that wouldn't offer the stability or predictability companies need. The protectionist actions by the Trump administration seem to have changed that relationship, but U.S.
    England claim friendly win over Super Eagles

    England claim friendly win over Super Eagles

    He has kept working hard, kept his focus and I think you saw a performance that, apart from scoring a goal, he was very lively. Gary Cahill powered home the opener on seven minutes before Harry Kane fired home with 39 minutes on the clock.
  • New Gmail launches for everyone in July

    New Gmail launches for everyone in July

    For G-Suite users (that's Gmail's business version), change to new Gmail at this point has to come at the organizational level. The newly designed Gmail has been an option for Gmail users for the past month but soon it will be the only choice.
    Android gets publicly shamed on stage at Apple's WWDC '18 event

    Android gets publicly shamed on stage at Apple's WWDC '18 event

    Most excitingly many expect to see support for sleep monitoring, after Apple acquired sleep startup Beddit in May a year ago . The event will kick start at 10 am PT, which means that the WWDC 2018 will start in India at 10:30 pm IST.
    Here’s When Apple’s WWDC 2018 Event Will Start In Your Region

    Here’s When Apple’s WWDC 2018 Event Will Start In Your Region

    The Cupertino-based firm, at its upcoming WWDC 2018 , is said to launch a new feature that aims to make this rumour a reality. Still, there's a chance he could mention immigration, gun control, or just wish everyone a happy Pride month.
  • Google reportedly not renewing contract for Project Maven drone program

    Google reportedly not renewing contract for Project Maven drone program

    Google Cloud CEO Diane Greene announced the decision at a meeting with employees Friday morning, three sources told Gizmodo . Unfortunately for Greene, mass upheavals forced her to tactfully reassess.
    Apple Adds More Fitness Features, Walkie-Talkie App to Its Watch

    Apple Adds More Fitness Features, Walkie-Talkie App to Its Watch

    Workouts now support yoga and hiking , both measure heart rate to gauge performance. watchOS 5 is also getting a Podcasts app. Additionally, the Siri watch face introduced past year is gaining live sports scores, commute time, and heart-rate tracking.
    United States  first lady Melania Trump to skip G7, North Korea summit

    United States first lady Melania Trump to skip G7, North Korea summit

    Trump is scheduled to join the president Monday in hosting a reception, closed to the press, for Gold Star families. On May 14 she was admitted to Walter Reed National Military Medical Center in Maryland for the kidney procedure.